A Latin American Perspective on Ion Channels

Ana Belén Elgoyhen and Carlos Barajas-López

Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, “Héctor N Torres,” Consejo Nacional de Investigaciones Científicas y Técnicas and Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina (A.B.E.), and División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, México (C.B.-L.) Received June 6, 2016; accepted July 8, 2016

ABSTRACT

Ion channels, both ligand- and voltage-gated, play fundamental roles in many physiologic processes. Alteration in ion channel function underlies numerous pathologies, including hypertension, diabetes, chronic pain, epilepsy, certain cancers, and neuromuscular diseases. In addition, an increasing number of inherited and de novo ion channel mutations have been shown to contribute to disease states. Ion channels are thus a major class of pharmacotherapeutic targets.

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